Oxidative Stress in Fibromyalgia

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Robin Thomas's picture
Robin Thomas
Title: LumiGRATE Poster - Top of the Totem Pole
Joined: Aug 21 2010
Posts: 94
User offline. Last seen 11 years 16 weeks ago.

I was invited to share the following blog post on oxidative stress as it related to fibromyalgia.  The original post can be found at http://robinthomas.biz I plan to continue this series, taken from a recent webcast.  If anyone would like to hear the entire webcast, contact me and I will be able to send an MP3 file.  Robin

In my recent teleseminar with Cynda Crawford about Fibromyalgia and Chronic Fatigue Syndrome, I discussed oxidative stress in Fibromyalgia and Chronic Fatigue Syndrome. I want to share some of that discussion with my readers.

In one of Dr. Strand’s studies, this patient’s complaints underline many of the typical symptoms in fibromyalgia patients.

“For a year or more I had chills, a stiff neck that came and went. Almost constant ear pain, with a number of ear infections and tiredness. Sensitivity to cold which eventually became painful to my muscles, irritable bowel, water retention, mental fog, & bruising, nightly sleep disruption. I felt drained of all energy constantly. Getting 10 – 12 hours sleep at night and 3 – 6 hour naps was never enough. This would not give me back the energy level that I was so used to. The almost daily 40 minute walks never energized me; I just felt more drained.”

Fibromyalgia is a chronic condition that causes widespread pain in muscles, tendons, and ligaments. The main symptoms are a dull, aching pain throughout the body; chronic fatigue; and tender points on both sides of the body, above and below the waist.

People also suffer from sleep problems and disorders: from a feeling of exhaustion regardless of the amount of daily sleep to experiencing co-existing conditions, like restless legs syndrome and sleep apnea. Studies show that fibromyalgia sufferers do not experience deep, restorative sleep. In addition to overall muscle pain, people also experience increased pain in certain body parts, such as:

  • the back of the head
  • between the shoulder blades
  • top of the shoulders
  • front sides of the neck
  • upper chest
  • outer elbows
  • upper part and side of the hips
  • the inner knees

Medical literature shows there is usually one of three different events that can trigger fibromyalgia or chronic fatigue.

  • serious illness, such as chronic infections or other prolonged illness.
  • physical injury or trauma to your body, particularly to the neck and head area.
  • severe or prolonged emotional stress.

Typically, it can be a combination of any of these factors. All three events significantly increase the number of free radicals you produce and can certainly lead to oxidative stress.

Clinical studies support that patients diagnosed with fibromyalgia have significantly lower antioxidative status as compared to those in a control group.

In 2009 and 2010, new studies from Turkey and Spain are corroborating the relationship between oxidative stress and the multiple symptoms of fibromyalgia, including pain. Other studies at Vanderbilt were inconclusive, though they did show a significant correlation with oxidative stress and fatigue.

The research on oxidative stress is important to consider when discussing the chronic conditions of fibromyalgia and chronic fatigue syndrome. In my next post, I’ll explain oxidative stress in more detail.

Be Well!

Robin

Information for this article was taken from a number of sources:
Dr. Ray Strand’s latest book Bionutrition
http://mayoclinic.com
Redox Rep. 2006 Altindag O, Celik H;11(3):131-5. Department of Physical Medicine and Rehabilitation, Harran University, Sanliurfa,Turkey. Total antioxidant capacity and the severity of the pain in patients with fibromyalgia.
Clin Rheumatol. 2009 Apr;28(4):435-8. Epub 2008 Dec 17. Chung CP, Titova D, Oeser A, Randels M, Avalos I, Milne GL, Morrow JD, Stein CM Department of Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232-6602, USA. Oxidative stress in fibromyalgia and its relationship to symptoms.
Stress. 2010 Jul 28. [Epub ahead of print] Nazıroğlu M, Akkuş S, Soyupek F, Yalman K, Celik O, Eriş S, Uslusoy GA. Department of Biophysics, Medical Faculty, Suleyman Demirel University, Isparta, Vitamins C and E treatment combined with exercise modulates oxidative stress markers in blood of patients with fibromyalgia: A controlled clinical pilot study.
__________________

Robin started contributing to  Lumigrate in August 2010.  "Meet Robin Thomas", a topic in our biographies/vitae forum is at http://www.lumigrate.com/forum/meet-robin-thomas to read all about her journey, which was greatly influenced by the need to help solve her youngest son's significant health challenges. For those who want just the overview here: After working over 22 years in medical research at the University of North Carolina on chronic inflammatory diseases she switched her focus to preventive health in 2004 when she was introduced to USANA Health Sciences.   Robin is passionate about helping others improve their health, have more energy, manage their weight, and improve their skin. 

I love meeting new friends !

LIKE me on Facebook      Connect on LinkedIn

Follow me on Twitter        Learn more at my BLOG

"I dream of a world free from pain and suffering. I dream of a world free from disease. The USANA family will be the healthiest family on earth. Share my vision. Love life and live it to its fullest in happiness and health."

-Dr. Myron Wentz, Founder and Chairman, USANA Health Sciences

 

Mardy Ross's picture
Mardy Ross
Title: LumiGRATE Poster - Top of the Totem Pole
Joined: Feb 16 2009
Posts: 2032
User offline. Last seen 46 weeks 2 days ago.
Thank you for accepting my invitation, Robin!

So I'm stressed and have been described as a radical, so THAT explains a few things!  

Seriously, I very much appreciate how much time you have put into your writings, which come with your background in your formal training in science and as I like to also underscore, combined with a dose of practical life experience looking into chronic illnesse in your family and what YOU think is the way to go about solving it.

I look forward to learning more about this topic and seeing how Lumigrate can help you reach others with your top notch information.  ~~ Mardy

__________________

Live and Learn. Learn and Live Better! is my motto. I'm Mardy Ross, and I founded Lumigrate in 2008 after a career as an occupational therapist with a background in health education and environmental research program administration. Today I function as the desk clerk for short questions people have, as well as 'concierge' services offered for those who want a thorough exploration of their health history and direction to resources likely to progress their health according to their goals. Contact Us comes to me, so please do if you have questions or comments. Lumigrate is "Lighting the Path to Health and Well-Being" for increasing numbers of people. Follow us on social networking sites such as: Twitter: http://twitter.com/lumigrate and Facebook. (There is my personal page and several Lumigrate pages. For those interested in "groovy" local education and networking for those uniquely talented LumiGRATE experts located in my own back yard, "LumiGRATE Groove of the Grand Valley" is a Facebook page to join. (Many who have joined are beyond our area but like to see the Groovy information! We not only have FUN, we are learning about other providers we can be referring patients to and 'wearing a groove' to each other's doors -- or websites/home offices!) By covering some of the things we do, including case examples, it reinforces the concepts at Lumigrate.com as well as making YOU feel that you're part of a community. Which you ARE at Lumigrate!

Robin Thomas's picture
Robin Thomas
Title: LumiGRATE Poster - Top of the Totem Pole
Joined: Aug 21 2010
Posts: 94
User offline. Last seen 11 years 16 weeks ago.
What is Oxidative Stress Anyway?

Here is a second article in my series about oxidative stress and fibromyalgia.  Actually, this is a general descriptive article about oxidative stress itself.  I will also have another article on how we can work on reducing oxidative stress in our daily lives.   Robin

In my last post, I discussed the symptoms and possible causes of fibromyalgia. Typical symptoms include widespread pain, chronic fatigue, tender points, and sleep disorders. Recent medical studies are reporting a correlation between oxidative stress with chronic fatigue and fibromyalgia. 

So, what is oxidative stress? Take a look at this picture, which shows some of the ways each and every one of us is exposed to oxidative stress, or an overabundance and attack of free radicals.
Free radicals can be generated by polluted environment, like pollution in our air, water, or food. They can also be generated by electromagnetic waves, radiation, cigarette smoke, alcohol, stress, and even excessive exercise. Sometimes we can do our best to avoid toxic exposures, but many times we have less control.  
A friend of mine once said, “There is only one very simple way to stop oxidative stress in our body … stop breathing.” Of course, oxygen is necessary for life. :)    Obviously, this is not the solution to preventing exposure to toxins.


To understand how free radicals form in first place, it’s important to understand how our body creates energy. In every cell of our body, we have a ‘furnace’ called the mitochondria.  As we breathe, oxygen is utilized within the mitochondria to create energy. Occasionally, a charged oxygen molecule is created. This charged molecule is called a free radical. 
 
This free radical has at least one unpaired electron in its outer orbit, which essentially gives it an electrical charge. The charged oxygen molecule becomes very unstable and reactive.  It attacks other cells to seek electrons to pair with its missing electrons.

If they are not readily neutralized by an antioxidant, they can go on to create more volatile free radicals, which can then damage the cell wall, vessel wall, proteins, fats, and even DNA.  The continuous attack on the body is oxidative stress. At this stage, it’s crucial to counterattack the effects of these free radicals in order to prevent severe illness. When the body is attacked by many free radicals, it falls ill. 
New research shows a correlation between oxidative stress and fibromyalgia and chronic fatigue. It’s important to understanding the dynamics of oxidative stress and its affect on our bodies. With a quality antioxidant program, you can prevent serious illnesses, such as fibromyalgia and chronic fatigue.

Be Well!

Robin

__________________

Robin started contributing to  Lumigrate in August 2010.  "Meet Robin Thomas", a topic in our biographies/vitae forum is at http://www.lumigrate.com/forum/meet-robin-thomas to read all about her journey, which was greatly influenced by the need to help solve her youngest son's significant health challenges. For those who want just the overview here: After working over 22 years in medical research at the University of North Carolina on chronic inflammatory diseases she switched her focus to preventive health in 2004 when she was introduced to USANA Health Sciences.   Robin is passionate about helping others improve their health, have more energy, manage their weight, and improve their skin. 

I love meeting new friends !

LIKE me on Facebook      Connect on LinkedIn

Follow me on Twitter        Learn more at my BLOG

"I dream of a world free from pain and suffering. I dream of a world free from disease. The USANA family will be the healthiest family on earth. Share my vision. Love life and live it to its fullest in happiness and health."

-Dr. Myron Wentz, Founder and Chairman, USANA Health Sciences

 

Robin Thomas's picture
Robin Thomas
Title: LumiGRATE Poster - Top of the Totem Pole
Joined: Aug 21 2010
Posts: 94
User offline. Last seen 11 years 16 weeks ago.
Reducing Oxidative Stress

In my last couple of posts, I’ve been discussing the relationship of oxidative stress and fibromyalgia. Research shows that people suffering from fibromyalgia and chronic fatigue syndrome have a higher incidence of oxidative stress. So, what can we do to reduce it? Fortunately, there are several things you can do, and all of them are within your control.
 
1. Practice moderate (not excessive) exercise. For some people, this may mean a 20-minute walk.  If you have fibromyalgia in particular, you want to be careful about not overdoing it. Stick to a mild exercise program every other day because strenuous exercise can increase oxidative stress. For people in the overall population, our bodies adjust, but too much exercise can overwhelm fibromyalgia and set off an exacerbation of the illness.  Dr. Strand recommends his most affected fibromyalgia patients start off by walking 5 minutes at a time and slowly build up to 20-30 minutes every other day.  Mild weight resistance can be useful but never two days in a row. 
2. Prevent excessive stress whenever possible. While we often cannot control the stress that is happening in our lives, we can make a difference in how we react. Effective stress reducing techniques include meditation, prayer, deep breathing, yoga, and biofeedback methods.
3. Reduce environmental toxins, such as pollutants in our air, water, and food. You may not realize that many environmental toxins exist in our water, air, and food, such as pesticides, heavy metals, and PCBs. Toxins kill through oxidative stress mechanisms. Many people with fibromyalgia have multiple chemical sensitivities, so reducing toxicities can make a big impact on their lives.
4. Avoid cigarette smoke. Stopping smoking is a smart, healthful decision, as cigarette smoke is a major source of toxins both for smokers and others affected by second-hand smoke.
5. Balance your exposure to sun. In the past, we have been told to stay out of the sun to avoid the damaging radiation. Now we find that low levels of vitamin D is causing (or exacerbating)  many chronic health conditions, including fibromyalgia. It is important to have your doctor test your blood level of vitamin D: serum levels of 25-hydroxyvitamin D >50 nmol/L is optimal. Supplementation may be necessary. A good way to increase your production of vitamin D is getting 15-20 minutes of midday sun. What a great reason to have your lunch outdoors!  
6. Be proactive to medications and diagnostic, or radiation treatments. It is important to discuss with your physician the pros and cons of any new medications as well as any multiple diagnostic procedures that include radiation. Sometimes we tend to get on what I call the medication rollercoaster:  adding medications to counteract the symptoms and side effects of medications we are already taking. It can end up as a chemical overload, which is not the best situation for those of us with multiple chemical sensitivities.
7. Eat a healthful diet. Some foods to avoid include refined sugar and any foods which spike your blood sugar level. By eating a low-glycemic diet, you can prevent a rollercoaster of blood sugars, which can cause brain fog and the release of stress hormones. One way to enhance your healthful foods is by increasing omega-3 foods, especially for people with fibromyalgia who often suffer from multiple food sensitivities, including wheat and dairy products. Nutritionist Julianne Koritz shows case studies of the improvements by people who eliminated harmful foods and improved their diets.
8. Use high quality supplementsA proper supplementation program can be the most important step to regaining your health. Here’s a paradigm shift: the need for supplementation at optimal levels is crucial to battle oxidative stress. I will address the benefits of supplements in a future blog post, but it’s important to consider them as effective tools in helping you reduce free radicals and therefore oxidative stress.

Be Well!

Robin

references:

http://lpi.oregonstate.edu/ss02/vitamine.html  http://www.biochemsoctrans.org/bst/030/0280/0300280.pdf  http://www.ncbi.nlm.nih.gov/pubmed/19913560

http://helpguide.org/mental/stress_management_relief_coping.htm http://www.mayoclinic.com/health/meditation/HQ01070

http://www.fibromyalgia-symptoms.org/environmental_therapy.html

http://cfpub.epa.gov/ncea/hero/index.cfm?action=search.view&reference_id=50458

http://www.fibromyalgia-symptoms.org/fibromyalgia_multiple_chemical.html

http://www.diet.com/dietblogs/read_blog.php?title=Reduce+Oxidative+Stress+-+Eat+More+Omega-3+Fats&blid=19818  http://www.nutraingredients.com/Research/Omega-3-shows-benefits-against-oxidative-stress-Study

__________________

Robin started contributing to  Lumigrate in August 2010.  "Meet Robin Thomas", a topic in our biographies/vitae forum is at http://www.lumigrate.com/forum/meet-robin-thomas to read all about her journey, which was greatly influenced by the need to help solve her youngest son's significant health challenges. For those who want just the overview here: After working over 22 years in medical research at the University of North Carolina on chronic inflammatory diseases she switched her focus to preventive health in 2004 when she was introduced to USANA Health Sciences.   Robin is passionate about helping others improve their health, have more energy, manage their weight, and improve their skin. 

I love meeting new friends !

LIKE me on Facebook      Connect on LinkedIn

Follow me on Twitter        Learn more at my BLOG

"I dream of a world free from pain and suffering. I dream of a world free from disease. The USANA family will be the healthiest family on earth. Share my vision. Love life and live it to its fullest in happiness and health."

-Dr. Myron Wentz, Founder and Chairman, USANA Health Sciences

 

Robin Thomas's picture
Robin Thomas
Title: LumiGRATE Poster - Top of the Totem Pole
Joined: Aug 21 2010
Posts: 94
User offline. Last seen 11 years 16 weeks ago.
Oxidative Stress in Fibromyalgia: the need for supplementation

In my last article, I shared a number of ways to reduce oxidative stress.  Whether or not you are experiencing fibromyalgia, supplementation using high quality products are key to counter-acting free radicals and thus oxidative stress. 

 

For more than 50 years, the general public has been led to believe that RDA nutrient levels are adequate…

 

…but adequate for what? Adequate to prevent clinically obvious nutritional deficiencies like scurvy, beriberi, rickets, and pellagra?

According to the Food and Nutrition Board (under the umbrella of the National Institute of Health) :

The Recommended Dietary Allowance (RDA) is the average daily dietary intake level that is sufficient to meet the requirement of nearly all apparently healthy individuals in a particular life stage and gender group.”

The Food and Nutrition Board further defines “requirement” as:

“…the lowest continuing intake level of a nutrient that, for a specified indicator of adequacy, will maintain a defined level of nutrition in an individual.”

Basically, the RDA is – by definition – the lowest level of nutrient intake necessary to prevent deficiencies. This is clearly important for helping individuals avoid acute deficiency diseases, but it fails to address the issue of optimal nutrition.

It is wonderful that the RDAs have been so successful in reducing blatant deficient diseases (including scurvy, pellagra, rickets and beriberi) to their lowest levels in recorded history. It is also good that products based on RDA amounts help combat deficiency diseases by providing minimal amounts of important vitamins and minerals.

However, as more and more of the general population is able to meet minimal nutrient requirements, new questions arise. For example, are RDA levels of vitamins and minerals enough to help prevent other degenerative diseases?  What about providing protection from oxidative damage?

I believe there are more benefits to nutritional supplementation than merely preventing increasingly rare deficiency diseases.

The important choice now is to use supplements formulated with the most up-to-date nutritional research in mind, which may or may not have relevance to the RDAs. Rather than just looking to prevent total vitamin deficiencies, we must be concerned with the vast majority of people who are “apparently” healthy. Many degenerative diseases and chronic illnesses develop over a lifetime, striking otherwise healthy individuals when they least expect it. or the millions of “apparently” healthy individuals in the world, minimal nutrient intakes may not be adequate to address modern health challenges.

One question that commonly arises is, “if I eat a healthy diet, do I still need to take supplements?” Let it be clearly stated that a healthy diet is a necessary foundation for any program of optimal nutrition, and there is no substitute for eating well. In this context,  nutritional supplements are designed to complement a healthy diet, not replace it.  High quality supplements are designed to provide advanced levels of vitamins, minerals, and antioxidants that are difficult to obtain from diet alone – levels that individuals can use every day to promote a lifetime of good health.

In June 2002, the Journal of the American Medical Association published two articles by health researchers at Harvard University. The articles were entitled “Vitamins for Chronic Disease Prevention in Adults“. Through their research, these independent researchers concluded:

“…suboptimal intake of some vitamins, above levels causing classic vitamin deficiency, is a risk factor for chronic diseases and common in the general population, especially the elderly. Suboptimal folic acid levels, along with suboptimal levels of vitamins B6 and B12, are a risk factor for cardiovascular disease, neural tube defects, and colon and breast cancer; low levels of vitamin D contribute to osteopenia and fractures; and low levels of the antioxidant vitamins (vitamins A, E and C) may increase risk for several chronic diseases.”

The scientific evidence supporting health benefits of nutritional supplements is solid and growing daily, and more health care professionals than ever before are now siding with these conclusions.

Be Well!

Robin

REFERENCES OF INTEREST
 Bendich A, Mallick R, Leader S. Potential health economic benefits of vitamin supplementation. West J Med 1997 May; 166(5):306-12. This study used published relative risk estimates for birth defects, premature birth, and coronary heart disease associated with vitamin intake to project potential annual cost reductions in U.S. hospitalization charges.

Fairfield KM, Fletcher RH. Vitamins for chronic disease prevention in adults: scientific review. JAMA 2002; 287:3116-3126. CONTEXT: Although vitamin deficiency is encountered infrequently in developed countries, inadequate intake of several vitamins is associated with chronic disease.

Fletcher RH, Fairfield KM. Vitamins for chronic disease prevention in adults: clinical applications. JAMA 2002; 287:3127-3129. Vitamin deficiency syndromes such as scurvy and beriberi are uncommon in Western societies. However, suboptimal intake of some vitamins, above levels causing classic vitamin deficiency, is a risk factor for chronic diseases and common in the general population, especially the elderly.

Kant AK. Consumption of energy-dense, nutrient-poor foods by adult Americans: nutritional and health implications. The third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 2000 Oct; 72(4):929-36. BACKGROUND: Current dietary guidance recommends limiting the intake of energy-dense, nutrient-poor (EDNP) foods, but little is known about recent consumption patterns of these foods.

Patterson BH, Harlan LC, Block G, Kahle L. Food choices of whites, blacks, and Hispanics: data from the 1987 National Health Interview Survey. Nutr Cancer 1995;23(2):105-19. Dietary guidelines posit an association between diet and cancer. Different cancer mortality rates among whites, blacks, and Hispanics may be related to differences in diet.

Starkey LJ, Johnson-Down L, Gray-Donald K. Food habits of Canadians: comparison of intakes in adults and adolescents to Canada’s food guide to healthy eating. Can J Diet Pract Res 2001 Summer;62(2):61-9. Over 25 years have elapsed since national food and nutrient intake data became available in Canada. Our goal was to describe present dietary intakes based on sociodemographic and 24-hour recall dietary interviews with adults and adolescents from households across the country.

Nicklas TA, Baranowski T, Baranowski JC, Cullen K, Rittenberry L, Olvera N. Family and child-care provider influences on preschool children’s fruit, juice, and vegetable consumption. Nutr Rev 2001 Jul;59(7):224-35. Children’s intakes of fruit, juice, and vegetables (FJV) do not meet the recommended minimum of five daily servings, placing them at increased risk for development of cancer and other diseases.

__________________

Robin started contributing to  Lumigrate in August 2010.  "Meet Robin Thomas", a topic in our biographies/vitae forum is at http://www.lumigrate.com/forum/meet-robin-thomas to read all about her journey, which was greatly influenced by the need to help solve her youngest son's significant health challenges. For those who want just the overview here: After working over 22 years in medical research at the University of North Carolina on chronic inflammatory diseases she switched her focus to preventive health in 2004 when she was introduced to USANA Health Sciences.   Robin is passionate about helping others improve their health, have more energy, manage their weight, and improve their skin. 

I love meeting new friends !

LIKE me on Facebook      Connect on LinkedIn

Follow me on Twitter        Learn more at my BLOG

"I dream of a world free from pain and suffering. I dream of a world free from disease. The USANA family will be the healthiest family on earth. Share my vision. Love life and live it to its fullest in happiness and health."

-Dr. Myron Wentz, Founder and Chairman, USANA Health Sciences

 

This forum is provided to allow members of Lumigrate to share information and ideas. Any recommendations made by forum members regarding medical treatments, medications, or procedures are not endorsed by Lumigrate or practitioners who serve as Lumigrate's medical experts.

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